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MLH1 PROTEIN
Descriptors Found:
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DeCS
Descriptor
English
:
MutL Protein Homolog 1
Descriptor
Spanish
:
Homólogo 1 de la Proteína MutL
Descriptor
Portuguese
:
Proteína 1 Homóloga a MutL
Synonyms
English
:
COCA2 Protein
Colon Cancer, Nonpolyposis Type 2 Protein
MLH1 Protein
MutL Homolog 1
Tree Number:
D08.811.074.766.500
D08.811.277.040.025.215.500
D12.776.260.540.500
Definition
English
:
Eukaryotic homolog of the bacterial MutL
DNA MISMATCH REPAIR
protein. It heterodimerizes with
MISMATCH REPAIR ENDONUCLEASE PMS2
to form MutL alpha, which is recruited to DNA mismatch sites by the
MUTS DNA MISMATCH-BINDING PROTEIN
.
Mutations
in the human MLH1 gene are associated with
COLORECTAL NEOPLASMS
, HEREDITARY NONPOLYPOSIS.
History Note
English
:
2017
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
56467
Unique Identifier:
D000070957
Occurrence in VHL
:
Similar:
DeCS
CID-10
LILACS